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CARIS LIFE SCIENCES INC (CAI)

Sector: Health Care

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2026 Annual Meeting Analysis

CARIS LIFE SCIENCES INC · Meeting: June 4, 2026

Policy v1.2high confidenceView Filing ↗
For informational purposes only. This AI-generated analysis applies a published voting policy to publicly available proxy filings. It does not constitute investment advice, proxy voting advice, or a solicitation of any kind. AI analysis may be incomplete or inaccurate — always review the actual filing and make your own independent decision.

Directors FOR

2

Directors AGAINST

8

Say on Pay

AGAINST

Auditor

FOR

Director Elections

Election of Directors

2 FOR/8 AGAINST

Against Analysis

✗ AGAINST
David Dean Halbert⚑ TSR trigger: CAI 3-year return -28.8% vs XBI (SPDR S&P Biotech ETF) 3-year return +68.7%, gap of -97.5pp exceeds 30pp threshold for negative absolute TSR⚑ Familial relationship: brother of fellow director Jon S. Halbert⚑ Combined CEO and Chairman role with no separation

As founder, CEO, Chairman, and a director since 2008, Mr. Halbert has presided over a stock decline of approximately 29% while the XBI (SPDR S&P Biotech ETF) rose roughly 69% over the same period — a gap of about 97.5 percentage points, far exceeding the 30-point threshold that triggers a AGAINST vote; additionally, he has a familial relationship with fellow director Jon S. Halbert (his brother), which is an independent governance concern.

✗ AGAINST
Peter M. Castleman⚑ TSR trigger: CAI 3-year return -28.8% vs XBI (SPDR S&P Biotech ETF) 3-year return +68.7%, gap of -97.5pp exceeds 30pp threshold for negative absolute TSR⚑ Director since 2008 — tenure fully overlaps underperformance period

Mr. Castleman has served as a director since 2008 and his entire tenure overlaps the period during which CAI's stock fell roughly 29% while the XBI (SPDR S&P Biotech ETF) gained about 69%, a gap of approximately 97.5 percentage points that far exceeds the 30-point policy threshold for companies with negative absolute returns; the 5-year return is identical to the 3-year return (-28.8%) so the 5-year mitigant does not apply.

✗ AGAINST
Brian J. Brille⚑ TSR trigger: CAI 3-year return -28.8% vs XBI (SPDR S&P Biotech ETF) 3-year return +68.7%, gap of -97.5pp exceeds 30pp threshold for negative absolute TSR⚑ Director since 2018 — tenure fully overlaps underperformance period⚑ Non-independent executive director (Vice Chairman and EVP)

Mr. Brille has served as a director since 2018, meaning his tenure fully overlaps the measurement period during which CAI's stock fell roughly 29% while the XBI (SPDR S&P Biotech ETF) gained about 69%, a gap of approximately 97.5 percentage points that far exceeds the 30-point policy threshold; the 5-year return is identical (-28.8%) so no mitigant applies.

✗ AGAINST
Joseph E. Gilliam⚑ TSR trigger: CAI 3-year return -28.8% vs XBI (SPDR S&P Biotech ETF) 3-year return +68.7%, gap of -97.5pp exceeds 30pp threshold for negative absolute TSR⚑ Director since April 2021 — tenure fully overlaps underperformance period

Mr. Gilliam has served as a director since April 2021, meaning his full tenure overlaps the period in which CAI's stock fell roughly 29% while the XBI (SPDR S&P Biotech ETF) gained about 69%, a gap of approximately 97.5 percentage points that far exceeds the 30-point policy threshold; the 5-year return is the same as the 3-year return so no mitigant applies.

✗ AGAINST
Jon S. Halbert⚑ TSR trigger: CAI 3-year return -28.8% vs XBI (SPDR S&P Biotech ETF) 3-year return +68.7%, gap of -97.5pp exceeds 30pp threshold for negative absolute TSR⚑ Director since 2014 — tenure fully overlaps underperformance period⚑ Familial relationship: brother of CEO David Dean Halbert — independence concern

Mr. Jon Halbert has been a director since 2014, his tenure fully overlaps the underperformance period in which CAI's stock fell roughly 29% against the XBI (SPDR S&P Biotech ETF) gain of about 69% (a gap of approximately 97.5 percentage points), far exceeding the 30-point threshold; additionally, as the brother of CEO David Dean Halbert, he presents a familial relationship concern that is an independent negative factor under our policy.

✗ AGAINST
Laura I. Johansen⚑ TSR trigger: CAI 3-year return -28.8% vs XBI (SPDR S&P Biotech ETF) 3-year return +68.7%, gap of -97.5pp exceeds 30pp threshold for negative absolute TSR⚑ Director since 2008 — tenure fully overlaps underperformance period⚑ Previously served as President of Caris and as President of the CEO's family office — close historical ties to management

Ms. Johansen has served as a director since the company's founding in 2008, fully spanning the period in which CAI's stock fell roughly 29% while the XBI (SPDR S&P Biotech ETF) gained about 69%, a gap of approximately 97.5 percentage points that far exceeds the 30-point threshold; her prior role as President of the CEO's family office also raises independence concerns.

✗ AGAINST
Lloyd B. Minor, M.D.⚑ TSR trigger: CAI 3-year return -28.8% vs XBI (SPDR S&P Biotech ETF) 3-year return +68.7%, gap of -97.5pp exceeds 30pp threshold for negative absolute TSR⚑ Director since August 2021 — tenure fully overlaps underperformance period

Dr. Minor joined the board in August 2021, meaning his full tenure overlaps the period in which CAI's stock fell roughly 29% while the XBI (SPDR S&P Biotech ETF) gained about 69%, a gap of approximately 97.5 percentage points that far exceeds the 30-point policy threshold; no 5-year mitigant is available as the 5-year return equals the 3-year return.

✗ AGAINST
Danny Phillips⚑ TSR trigger: CAI 3-year return -28.8% vs XBI (SPDR S&P Biotech ETF) 3-year return +68.7%, gap of -97.5pp exceeds 30pp threshold for negative absolute TSR⚑ Director since August 2015 — tenure fully overlaps underperformance period

Mr. Phillips has served as a director since August 2015, meaning his entire tenure overlaps the period in which CAI's stock fell roughly 29% while the XBI (SPDR S&P Biotech ETF) gained about 69%, a gap of approximately 97.5 percentage points that far exceeds the 30-point threshold; the 5-year return equals the 3-year return so no mitigant is available.

For Analysis

✓ FOR
David Fredrickson⚑ Director since August 2024 — within 24-month new-director exemption

Mr. Fredrickson joined the board in August 2024, which is within the 24-month window during which new directors are exempt from the TSR underperformance trigger under our policy, so no TSR-based concern applies; he also brings relevant oncology and pharmaceutical industry experience.

✓ FOR
Jeffrey Vacirca, M.D.⚑ Director since November 2024 — within 24-month new-director exemption

Dr. Vacirca joined the board in November 2024, which falls within the 24-month new-director exemption from the TSR underperformance trigger under our policy; he brings relevant oncology clinical and executive experience and no other policy flags apply.

Eight of the ten director nominees receive an AGAINST vote due to severe TSR underperformance: CAI's stock fell approximately 29% over three years while the XBI (SPDR S&P Biotech ETF) rose roughly 69%, producing a gap of about 97.5 percentage points — more than three times the 30-point threshold for companies with negative absolute returns. Additional concerns include a familial relationship between CEO David Dean Halbert and director Jon S. Halbert, and the CEO's combined Chairman/CEO role. The two nominees who joined within the past 24 months (David Fredrickson and Jeffrey Vacirca) are exempt from the TSR trigger and receive a FOR vote.

Say on Pay

✗ AGAINST

CEO

David Dean Halbert

Total Comp

$20,350,571

Prior Support

N/A

⚑ No Say on Pay vote held — company is an emerging growth company exempt from advisory vote requirement⚑ CEO total compensation of $20,350,571 includes $1,500,000 in special IPO-related bonuses with no performance conditions⚑ Annual bonus program was fully discretionary for 2025 with no pre-set measurable performance targets⚑ Severe TSR underperformance: CAI stock -28.8% vs XBI (SPDR S&P Biotech ETF) +68.7% over 3 years while above-benchmark variable pay was awarded⚑ Pay-for-performance misalignment: above-benchmark incentive pay awarded despite significant underperformance vs XBI

Caris is an emerging growth company and is not required to hold a Say on Pay vote, and none appears on this ballot — however, because a CEO compensation block was provided for analysis, we note that the 2025 executive compensation program raises significant concerns: CEO David Dean Halbert received $20.4 million in total pay including $1.5 million in special bonuses tied to financing and IPO milestones (not long-term shareholder value creation) and a discretionary annual bonus with no pre-set measurable performance goals, which effectively means a large portion of variable pay was not truly tied to performance outcomes. The pay-for-performance alignment check fails because above-benchmark variable compensation was paid while the stock fell approximately 29% against the XBI (SPDR S&P Biotech ETF), which gained about 69% — a gap of roughly 97.5 percentage points — meaning shareholders experienced significant losses while executives received large pay packages. If a Say on Pay vote were presented, the policy determination would be AGAINST.

Auditor Ratification

✓ FOR

Auditor

Deloitte & Touche LLP

Tenure

2 yrs

Audit Fees

$2,950,934

Non-Audit Fees

$3,050

Deloitte was appointed in September 2024 and has served for approximately two years — well below the 25-year tenure threshold that would trigger concern; non-audit fees of $3,050 are a tiny fraction of audit fees of $2,950,934 (essentially 0%), far below the 50% ratio that would trigger a AGAINST vote; Deloitte is a Big 4 firm appropriate for a company of Caris's size and complexity.

Overall Assessment

The 2026 Caris Life Sciences annual meeting presents two formal proposals: director elections and auditor ratification. Eight of ten director nominees receive an AGAINST vote driven by extreme stock underperformance — CAI's shares fell roughly 29% over three years while the XBI (SPDR S&P Biotech ETF) gained about 69%, a gap of nearly 98 percentage points against the 30-point threshold — with additional concerns around familial relationships and governance structure; Deloitte ratification is supported given its recent appointment, Big 4 status, and negligible non-audit fees.

Filing date: April 23, 2026·Policy v1.2·high confidence